Synthesis, Characterization, Antimicrobial Screening and Free-Radical Scavenging Activity of Some Novel Substituted PyrazolesReportar como inadecuado


Synthesis, Characterization, Antimicrobial Screening and Free-Radical Scavenging Activity of Some Novel Substituted Pyrazoles


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Department of Chemistry, Faculty of Education, Alexandria University, Alexandria 21526, Egypt





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Author to whom correspondence should be addressed.



Academic Editor: Philippe Belmont

Abstract The present work deals with the synthesis of acetoxysulfonamide pyrazole derivatives, substituted 4,5-dihydropyrazole-1-carbothioamide and 4,5-dihydropyrazole-1-isonicotinoyl derivatives starting from substituted vanillin chalcones. Acetoxysulfonamide pyrazole derivatives were prepared from the reaction of chalcones with p-sulfamylphenylhydrazine followed by treatment with acetic anhydride. At the same time 4,5-dihydropyrazole-1-carbothioamide and 4,5-dihydropyrazole-1-isonicotinoyl derivatives were prepared from the reaction of chalcones with either thiosemicarbazide or isonicotinic acid hydrazide, respectively. The synthesized compounds were structurally characterized on the basis of IR, 1H-NMR, 13C-NMR spectral data and microanalyses. All of the newly isolated compounds were tested for their antimicrobial activities. The antimicrobial screening using the agar well-diffusion method revealed that the chloro derivatives are the most active ones. Moreover, the antioxidant and anti-inflammatory activity of these chloro derivatives are also studied using the DPPH radical scavenging and NO radical scavenging methods, respectively. View Full-Text

Keywords: chalcones; sulfonamide pyrazole; isonicotinic acid hydrazide; antimicrobial activity; antioxidant; anti-inflammatory chalcones; sulfonamide pyrazole; isonicotinic acid hydrazide; antimicrobial activity; antioxidant; anti-inflammatory





Autor: Nagwa Mohamed Mahrous Hamada * and Nadia Yousef Megally Abdo

Fuente: http://mdpi.com/



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