Antiviral, Antifungal and Antibacterial Activities of a BODIPY-Based PhotosensitizerReportar como inadecuado




Antiviral, Antifungal and Antibacterial Activities of a BODIPY-Based Photosensitizer - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

1

Department of Chemistry, North Carolina State University, Raleigh, NC 27695-8204, USA

2

Department of Biological Sciences, North Carolina State University, Raleigh, NC 27695-7614, USA





*

Author to whom correspondence should be addressed.



Academic Editor: Peter J. Rutledge

Abstract Antimicrobial photodynamic inactivation aPDI employing the BODIPY-based photosensitizer 2,6-diiodo-1,3,5,7-tetramethyl-8-N-methyl-4-pyridyl-4,4′-difluoro-boradiazaindacene DIMPy-BODIPY was explored in an in vitro assay against six species of bacteria eight total strains, three species of yeast, and three viruses as a complementary approach to their current drug-based or non-existent treatments. Our best results achieved a noteworthy 5–6 log unit reduction in CFU at 0.1 μM for Staphylococcus aureus ATCC-2913, methicillin-resistant S. aureus ATCC-44, and vancomycin-resistant Enterococcus faecium ATCC-2320, a 4–5 log unit reduction for Acinetobacter baumannii ATCC-19606 0.25 μM, multidrug resistant A. baumannii ATCC-1605 0.1 μM, Pseudomonas aeruginosa ATCC-97 0.5 μM, and Klebsiella pneumoniae ATCC-2146 1 μM, and a 3 log unit reduction for Mycobacterium smegmatis mc2155 ATCC-700084. A 5 log unit reduction in CFU was observed for Candida albicans ATCC-90028 1 μM and Cryptococcus neoformans ATCC-64538 0.5 μM, and a 3 log unit reduction was noted for Candida glabrata ATCC-15545 1 μM. Infectivity was reduced by 6 log units in dengue 1 0.1 μM, by 5 log units 0.5 μM in vesicular stomatitis virus, and by 2 log units 5 μM in human adenovirus-5. Overall, the results demonstrate that DIMPy-BODIPY exhibits antiviral, antibacterial and antifungal photodynamic inactivation at nanomolar concentrations and short illumination times. View Full-Text

Keywords: photodynamic therapy; singlet oxygen; antibacterial; antiviral; antifungal; photobiocidal photodynamic therapy; singlet oxygen; antibacterial; antiviral; antifungal; photobiocidal





Autor: Bradley L. Carpenter 1, Xingci Situ 1, Frank Scholle 2, Juergen Bartelmess 1, Walter W. Weare 1 and Reza A. Ghiladi 1,*

Fuente: http://mdpi.com/



DESCARGAR PDF




Documentos relacionados