Preparation, Characterization and Pharmacokinetic Study of Xiangfu Siwu Decoction Essential Oil-β-Cyclodextrin Inclusion ComplexReportar como inadecuado




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Jiangsu Key Laboratory for High Technology Research of Traditional Chinese Medicine Formulae, Nanjing University of Chinese Medicine, Nanjing 210023, China

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Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine, Nanjing 210023, China





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Authors to whom correspondence should be addressed.



Academic Editor: Maria Emília Sousa

Abstract Xiang-Fu-Si-Wu Decoction XFSWD, a famous Chinese herbal formula, is considered an effective prescription for treating primary dysmenorrhea. The essential oil is a significant effective ingredient of XFSWD. However, its volatility, instability and poor water-solubility influence its pharmacodynamic effects. β-Cyclodextrin β-CD has the intrinsic ability to form specific inclusion complexes with such drugs to enhance their stability, solubility and bioavailability. The aim of this study was thus to compare the pharmacokinetic characteristics and the oral bioavailability of XFSWD essential oil XEO and its β-CD inclusion complex after oral administration to rats. A simple, rapid, and sensitive ultra-high performance liquid chromatography tandem mass spectrometry UPLC-MS-MS method was developed for the simultaneous quantification of five active components of XEO in rat plasma. The in vivo data showed that XEO-β-CD inclusion complex displayed higher maximum plasma concentration Cmax, longer half-time T1-2 and bigger area under the concentration-time curve AUC0–24 h. These results demonstrated that the formation of β-CD inclusion complex has significantly increased the oral bioavailability of the drugs in rats than free oil. View Full-Text

Keywords: Xiangfu Siwu decoction; essential oil; β-cyclodextrin; inclusion complex; pharmacokinetics Xiangfu Siwu decoction; essential oil; β-cyclodextrin; inclusion complex; pharmacokinetics





Autor: Junzuan Xi 1,2, Dawei Qian 1,2,* , Jinao Duan 1,2,* , Pei Liu 1,2, Zhenhua Zhu 1,2, Jianming Guo 1,2, Yang Zhang 1,2 and Ying Pan 1,2

Fuente: http://mdpi.com/



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