Anti-Schistosomal Activity of Cinnamic Acid Esters: Eugenyl and Thymyl Cinnamate Induce Cytoplasmic Vacuoles and Death in Schistosomula of Schistosoma mansoniReport as inadecuate




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1

Institute of Pharmacy and Food Chemistry, University of Wuerzburg, Am Hubland, D-97074 Wuerzburg, Germany

2

Institute for Molecular Infection Biology, University of Wuerzburg, Josef-Schneider-Str. 2-D15, D-97080 Wuerzburg, Germany

3

Center for Discovery and Innovation in Parasitic Diseases, University of California, San Francisco, 1700 4th St., San Francisco, CA 94158, USA

4

Department of Pathology, University of California, San Francisco, CA 94158, USA



These authors contributed equally to this work.





*

Author to whom correspondence should be addressed.



Academic Editor: Thomas J. Schmidt

Abstract Bornyl caffeate 1 was previously isolated by us from Valeriana V. wallichii rhizomes and identified as an anti-leishmanial substance. Here, we screened a small compound library of synthesized derivatives 1–30 for activity against schistosomula of Schistosoma S. mansoni. Compound 1 did not show any anti-schistosomal activity. However, strong phenotypic changes, including the formation of vacuoles, degeneration and death were observed after in vitro treatment with compounds 23 thymyl cinnamate and 27 eugenyl cinnamate. Electron microscopy analysis of the induced vacuoles in the dying parasites suggests that 23 and 27 interfere with autophagy. View Full-Text

Keywords: Schistosoma; schistosomula; parasite; eugenyl cinnamate; thymyl cinnamate; vacuoles; autophagy; anti-schistosomal activity Schistosoma; schistosomula; parasite; eugenyl cinnamate; thymyl cinnamate; vacuoles; autophagy; anti-schistosomal activity





Author: Jan Glaser 1,†, Uta Schurigt 2,†,* , Brian M. Suzuki 3,4, Conor R. Caffrey 3,4 and Ulrike Holzgrabe 1

Source: http://mdpi.com/



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