Synthesis of Bicyclic Isoxazoles and Isoxazolines via Intramolecular Nitrile Oxide CycloadditionReport as inadecuate




Synthesis of Bicyclic Isoxazoles and Isoxazolines via Intramolecular Nitrile Oxide Cycloaddition - Download this document for free, or read online. Document in PDF available to download.

Department of Chemistry, National Taiwan Normal University, 88, Sec. 4, Ting-Chow Road, Taipei 116, Taiwan





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Academic Editor: Derek J. McPhee

Abstract An efficient and straight forward procedure for the syntheses of bicyclic isoxazole-isoxazoline derivatives from the corresponding dimethyl-2-2-nitro-1-aryl-alkyl-2-prop-2-yn-1ylmalonates or dimethyl 2-allyl-2-2-nitro-1-aryl-alkyl ethylmalonate is described. High yields and simple operations are important features of this methodology. View Full-Text

Keywords: bicyclic isoxazole-isoxazolines; cycloaddition; nitrile oxide; nitroalkane; Yamaguchi reagent bicyclic isoxazole-isoxazolines; cycloaddition; nitrile oxide; nitroalkane; Yamaguchi reagent





Author: Wen-Chang Chen, Veerababurao Kavala, Yu-Hsuan Shih, Yu-Hsuan Wang, Chun-Wei Kuo, Tang-Hao Yang, Chia-Yu Huang, Hao-Hsiang Chiu and Ching-Fa Yao *

Source: http://mdpi.com/



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