Development of Orally Active Thrombin Inhibitors for the Treatment of Thrombotic Disorder DiseasesReportar como inadecuado




Development of Orally Active Thrombin Inhibitors for the Treatment of Thrombotic Disorder Diseases - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Department of Medicinal Chemistry, Nanjing University of Chinese Medicine, Nanjing 210023, China





*

Authors to whom correspondence should be addressed.



Academic Editor: Derek J. McPhee

Abstract Thrombotic disorders represent the major share of the various cardiovascular diseases, and significant progress has been made in the development of synthetic thrombin inhibitors as new anticoagulants. In addition to the development of highly potent and selective inhibitors with improved safety and suitable half-life, several allosteric inhibitors have been designed and synthesized, that did not fully nullify the procoagulant signal and thus could result in reduced bleeding complications. Furthermore, natural products with thrombin inhibitory activity have been isolated, and some natural products have been modified in order to improve their inhibitory activity and metabolic stability. This review summarizes the development of orally active thrombin inhibitors for the treatment of thrombotic disorder diseases, which could serve as a reference for the interested researchers. View Full-Text

Keywords: thrombin; thrombotic disorders; allosteric inhibitors; natural products; orally active; coagulation; thrombosis thrombin; thrombotic disorders; allosteric inhibitors; natural products; orally active; coagulation; thrombosis





Autor: Li-Wei He, Wei-Chen Dai * and Nian-Guang Li *

Fuente: http://mdpi.com/



DESCARGAR PDF




Documentos relacionados