Protective Effects of Korean Red Ginseng against Alcohol-Induced Fatty Liver in RatsReport as inadecuate




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Department of Nutritional Science and Food Management, Ewha Womens University, 52 Ewhayeodae-gil, Seodaemun-gu, Seoul 120-750, Korea





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Academic Editor: Derek J. McPhee

Abstract The present study tested the hypothesis that Korean red ginseng KRG provides a protective effect against alcoholic fatty liver. Male Sprague-Dawley rats were divided into four groups and fed a modified Lieber-DeCarli diet containing 5% w-v alcohol or an isocaloric amount of dextrin-maltose for the controls for 6 weeks: normal control CON, alcohol control ET, and ET treated with 125 or 250 mg-kg body weight-day of KRG RGL or RGH, respectively. Compared with the CON group, the ET group exhibited a significant increase in triglycerides, total cholesterol and the presence of lipid droplets in the liver, and a decrease in fat mass, which were all attenuated by KRG supplementation in adose-dependent manner. The mitigation was accompanied by AMP-activated protein kinase AMPK signaling pathways in the liver and adipose tissue. In addition, suppression in the alcohol-induced changes of adipose adipokine mRNA expression was also observed in KRG supplementation group. These findings suggest that KRG may have the potential to ameliorate alcoholic fatty liver by suppressing inappropriate lysis of adipose tissue and preventing unnecessary de novo lipogenesis in the liver, which are mediated by AMPK signaling pathways. A mechanism for an interplay between the two organs is still needed to be examined with further assays. View Full-Text

Keywords: Korean red ginseng; alcoholic fatty liver; adipose tissue; AMP-activated protein kinase Korean red ginseng; alcoholic fatty liver; adipose tissue; AMP-activated protein kinase





Author: Hyo Jin Lee, Hyang Mok Ok and Oran Kwon *

Source: http://mdpi.com/



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