Antibacterial Activity and Mechanism of Action of Sulfone Derivatives Containing 1,3,4-Oxadiazole Moieties on Rice Bacterial Leaf BlightReportar como inadecuado




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State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University, Huaxi District, Guiyang 550025, China





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Academic Editor: Peter J. Rutledge

Abstract In this study, sulfone derivatives containing 1,3,4-oxadiazole moieties indicated good antibacterial activities against rice bacterial leaf blight caused by the pathogen Xanthomonas oryzaepv. pv. oryzae Xoo. In particular, 2-methylsulfonyl-5-4-fluorobenzyl-1,3,4-oxadiazole revealed the best antibacterial activity against Xoo, with a half-maximal effective concentration EC50 of 9.89 μg-mL, which was better than those of the commercial agents of bismerthiazole 92.61 μg-mL and thiodiazole copper 121.82 μg-mL. In vivo antibacterial activity tests under greenhouse conditions and field trials demonstrated that 2-methylsulfonyl-5-4-fluorophenyl-1,3,4-oxadiazole was effective in reducing rice bacterial leaf blight. Meanwhile, 2-methylsulfonyl-5-4-fluorophenyl-1,3,4-oxadiazole stimulate the increase in superoxide dismutase SOD and peroxidase POD activities in rice, causing marked enhancement of plant resistance against rice bacterial leaf blight. It could also improve the chlorophyll content and restrain the increase in the malondialdehyde MDA content in rice to considerably reduce the amount of damage caused by Xoo. Moreover, 2-methylsulfonyl-5-4-fluorophenyl-1,3,4-oxadiazole, at a concentration of 20 μg-mL, could inhibit the production of extracellular polysaccharide EPS with an inhibition ratio of 94.52%, and reduce the gene expression levels of gumB, gumG, gumM, and xanA, with inhibition ratios of 94.88%, 68.14%, 86.76%, and 79.21%, respectively. View Full-Text

Keywords: sulfone derivative; antibacterial activity; action mechanism; Xanthomonas oryzae pv. oryzae; extracellular polysaccharide sulfone derivative; antibacterial activity; action mechanism; Xanthomonas oryzae pv. oryzae; extracellular polysaccharide





Autor: Li Shi, Pei Li, Wenli Wang, Manni Gao, Zengxue Wu, Xianpeng Song and Deyu Hu *

Fuente: http://mdpi.com/



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