Biofunctional Constituents from Michelia compressa var. lanyuensis with Anti-Melanogenic PropertiesReport as inadecuate




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1

School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan

2

Department of Nursing, Tzu Hui Institute of Technology, Pingtung County 926, Taiwan

3

Department of Nutrition and Health Science, School of Medical and Health Sciences, Fooyin University, Kaohsiung 831, Taiwan





*

Authors to whom correspondence should be addressed.



Academic Editor: Derek J. McPhee

Abstract Seven compounds were extracted and purified from the roots of Michelia compressa var. lanyuensis. These compounds are liriodenine, −-N-acetylanonaine, pressalanine A, p-dihydroxybenzaldehyde, 3,4-dihydroxybenzoic acid, −-bornesitol and β-sitostenone. These compounds were screened for anti-proliferation and anti-tyrosinase activities in B16F10 cells. Liriodenine, pressalanine A, −-bornesitol and β-sitostenone displayed cytotoxicity at high concentration 100 μM, but liriodenine 5 μM, −-N-acetylanonaine 10 μM, and β-sitostenone 5 μM inhibit tyrosinase activity and reduce the melanin content in B16F10 cells without cytotoxicity, suggesting that liriodenine and β-sitostenone could be safe and potentially used in cosmetic skin whitening. View Full-Text

Keywords: Michelia compressa var. lanyuensis; Magnoliaceae; tyrosinase activity; melanin Michelia compressa var. lanyuensis; Magnoliaceae; tyrosinase activity; melanin





Author: Chia-Wei Chu 1, Chi-Ming Liu 2, Mei-Ing Chung 1,* and Chung-Yi Chen 3,*

Source: http://mdpi.com/



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