Enzyme Inhibitory Radicinol Derivative from Endophytic fungus Bipolaris sorokiniana LK12, Associated with Rhazya strictaReport as inadecuate




Enzyme Inhibitory Radicinol Derivative from Endophytic fungus Bipolaris sorokiniana LK12, Associated with Rhazya stricta - Download this document for free, or read online. Document in PDF available to download.

1

UoN Chair of Omans Medicinal Plants and Marine Natural Products, University of Nizwa, Birkat Al-Mouz, Nizwa 616, Oman

2

Department of Biological Sciences and Chemistry, College of Arts and Sciences, University of Nizwa, Birkat Al-Mouz, Nizwa 616, Oman

3

School of Applied Biosciences, Kyungpook National University, Daegu 702-701, Korea





*

Authors to whom correspondence should be addressed.



Academic Editor: Isabel C.F.R. Ferreira

Abstract Endophytes, living inside plant tissues, play an essential role in plant growth and development, whilst producing unique bioactive secondary metabolites. In the current study, the endophytic fungus Bipolaris sorokiniana LK12 was isolated from the leaves of ethno-medicinal and alkaloidal rich Rhazya stricta. The bulk amount of ethyl acetate extract of fungus was subjected to advance column chromatographic techniques, which resulted in the isolation of a new radicinol derivative, bipolarisenol 1. It was found to be a derivative of radicinol. The structure elucidation was carried out by the combined use of 1D and 2D nuclear magnetic resonance, infrared spectroscopy, mass, and UV spectrometric analyses. The bipolarisenol was assessed for its potential role in enzyme inhibition of urease and acetyl cholinesterase AChE. Results showed that bipolarisenol significantly inhibited the AChE activity with low IC50 67.23 ± 5.12 µg·mL−1. Bipolarisenol inhibited urease in a dose-dependent manner with high IC50 81.62 ± 4.61 µg·mL−1. The new compound also showed a moderate anti-lipid peroxidation potential IC50 = 168.91 ± 4.23 µg·mL−1. In conclusion, endophytes isolated from medicinal plants possess a unique potential to be considered for future drug discovery. View Full-Text

Keywords: radicinol; bipolarisenol; Rhazya stricta; Bipolaris sorokiniana LK12; lipid peroxidation; enzyme inhibition radicinol; bipolarisenol; Rhazya stricta; Bipolaris sorokiniana LK12; lipid peroxidation; enzyme inhibition





Author: Abdul Latif Khan 1, Liaqat Ali 1,* , Javid Hussain 1,2, Tania Shamim Rizvi 1, Ahmed Al-Harrasi 1,2,* and In-Jung Lee 3

Source: http://mdpi.com/



DOWNLOAD PDF




Related documents