Heterocycles 38. Biocatalytic Synthesis of New Heterocyclic Mannich Bases and DerivativesReportar como inadecuado




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1

Department of Organic Chemistry -Iuliu Haţieganu- University of Medicine and Pharmacy, 41 Victor Babeş street, RO-400012 Cluj-Napoca, Romania

2

Department of Biochemistry and Biochemical Engineering, Babeş-Bolyai University of Cluj-Napoca, 11 Arany János street, RO-400028 Cluj-Napoca, Romania





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Author to whom correspondence should be addressed.



Academic Editor: Wim Dehaen

Abstract This paper describes the biocatalytic synthesis of new Mannich bases containing various heterocyclic rings thiazole, furane, thiophene, pyridine by applying the lipase catalyzed trimolecular condensation of the corresponding heterocyclic aldehydes with acetone and primary aromatic amines, in mild and eco-friendly reaction conditions. The obtained Mannich bases were acylated to their corresponding N-acetyl derivatives. All compounds were characterized by 1H-NMR, 13C-NMR and MS spectrometry. View Full-Text

Keywords: Mannich reaction; heterocyclic compounds; lipase; biocatalytic promiscuity Mannich reaction; heterocyclic compounds; lipase; biocatalytic promiscuity





Autor: Denisa Leonte 1, László Csaba Bencze 2, Csaba Paizs 2, Florin Dan Irimie 2 and Valentin Zaharia 1,*

Fuente: http://mdpi.com/



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