Acerogenin A from Acer nikoense Maxim Prevents Oxidative Stress-Induced Neuronal Cell Death through Nrf2-Mediated Heme Oxygenase-1 Expression in Mouse Hippocampal HT22 Cell LineReport as inadecuate




Acerogenin A from Acer nikoense Maxim Prevents Oxidative Stress-Induced Neuronal Cell Death through Nrf2-Mediated Heme Oxygenase-1 Expression in Mouse Hippocampal HT22 Cell Line - Download this document for free, or read online. Document in PDF available to download.

1

Department of Biomedical Chemistry, College of Health and Biomedical Science, Konkuk University, Chung-Ju 380-701, Korea

2

Research Institute for Biological Functions, Chubu University, 1200 Matsumoto, Kasugai, Aichi 487-8501, Japan

3

College of Pharmacy, Wonkwang University, Iksan 570-749, Korea

4

Department of Biochemistry, Inha University School of Medicine, Incheon 400-712, Korea





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Academic Editor: Peter Koulen

Abstract Oxidative cell damage contributes to neuronal degeneration in many central nervous system CNS diseases such as Parkinson’s disease, Alzheimer’s disease, and ischemia. Inducible heme oxygenase HO-1 acts against oxidants that are thought to play a key role in the pathogenesis of neuronal diseases. The stem bark of Acer nikoense Maxim Aceraceae is indigenous to Japan; it has been used in folk medicine as a treatment of hepatic disorders and eye diseases. Acerogenin A, a natural compound isolated from Japanese folk medicine A. nikoense, showed neuroprotective effects and reactive oxygen species ROS reduction on glutamate-induced neurotoxicity by inducing the expression of HO-1 in mouse hippocampal HT22 cells. Furthermore, acerogenin A caused the nuclear accumulation of nuclear factor-E2-related factor 2 Nrf2 and the activation of the PI3K-AKT signaling pathways. In this study, we demonstrated that acerogenin A effectively prevents glutamate-induced oxidative damage, and HO-1 induction via PI3K-Akt and Nrf2 pathways appears to play a key role in the protection of HT22 cells. Therefore, this study implies that the Nrf2-HO-1 pathway represents a biological target and that acerogenin A might be a candidate for the prevention of neurodegeneration. View Full-Text

Keywords: acerogenin A; mouse hippocampal HT22 cells; neuro-protective effects; heme oxygenase-1; nuclear factor-E2-related factor 2 acerogenin A; mouse hippocampal HT22 cells; neuro-protective effects; heme oxygenase-1; nuclear factor-E2-related factor 2





Author: Dong-Sung Lee 1, Byung-Yoon Cha 2, Je-Tae Woo 2, Youn-Chul Kim 3 and Jun-Hyeog Jang 4,*

Source: http://mdpi.com/



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