Phytochemical Properties and Anti-Proliferative Activity of Olea europaea L. Leaf Extracts against Pancreatic Cancer CellsReportar como inadecuado




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1

Nutrition Food & Health Research Group, School of Environmental and Life Sciences, University of Newcastle, Ourimbah, NSW 2258, Australia

2

School of Biomedical Sciences and Pharmacy, University of Newcastle, Ourimbah, NSW 2258, Australia

3

Faculty of Bioscience Engineering, Ghent University Global Campus, Incheon 406-840, Korea





*

Author to whom correspondence should be addressed.



Academic Editor: Marcello Iriti

Abstract Olea europaea L. leaves are an agricultural waste product with a high concentration of phenolic compounds; especially oleuropein. Oleuropein has been shown to exhibit anti-proliferative activity against a number of cancer types. However, they have not been tested against pancreatic cancer, the fifth leading cause of cancer related death in Western countries. Therefore, water, 50% ethanol and 50% methanol extracts of Corregiola and Frantoio variety Olea europaea L. leaves were investigated for their total phenolic compounds, total flavonoids and oleuropein content, antioxidant capacity and anti-proliferative activity against MiaPaCa-2 pancreatic cancer cells. The extracts only had slight differences in their phytochemical properties, and at 100 and 200 μg-mL, all decreased the viability of the pancreatic cancer cells relative to controls. At 50 μg-mL, the water extract from the Corregiola leaves exhibited the highest anti-proliferative activity with the effect possibly due to early eluting HPLC peaks. For this reason, olive leaf extracts warrant further investigation into their potential anti-pancreatic cancer benefits. View Full-Text

Keywords: olive leaf; oleuropein; pancreatic cancer; phenolic compounds; Olea europaea L.; antioxidant activity; phytochemicals; biophenols olive leaf; oleuropein; pancreatic cancer; phenolic compounds; Olea europaea L.; antioxidant activity; phytochemicals; biophenols





Autor: Chloe D. Goldsmith 1,* , Quan V. Vuong 1, Elham Sadeqzadeh 2, Costas E. Stathopoulos 3, Paul D. Roach 1 and Christopher J. Scarlett 1

Fuente: http://mdpi.com/



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