Anti-Inflammatory Activities of Licorice Extract and Its Active Compounds, Glycyrrhizic Acid, Liquiritin and Liquiritigenin, in BV2 Cells and Mice LiverReport as inadecuate




Anti-Inflammatory Activities of Licorice Extract and Its Active Compounds, Glycyrrhizic Acid, Liquiritin and Liquiritigenin, in BV2 Cells and Mice Liver - Download this document for free, or read online. Document in PDF available to download.

1

Department of Molecular Medicine and Tissue Injury Defense Research Center, School of Medicine, Ewha Womans University, Yangchon-ku, Seoul 158-710, Korea

2

Life Science Research Institute, Novarex Co., Ltd, Ochang, Cheongwon, Chungbuk 363-885, Korea

3

College of Pharmacy, Pusan National University, Pusan 609-735, Korea





*

Authors to whom correspondence should be addressed.



Academic Editor: Derek J. McPhee

Abstract This study provides the scientific basis for the anti-inflammatory effects of licorice extract in a t-BHP tert-butyl hydrogen peroxide-induced liver damage model and the effects of its ingredients, glycyrrhizic acid GA, liquiritin LQ and liquiritigenin LG, in a lipopolysaccharide LPS-stimulated microglial cell model. The GA, LQ and LG inhibited the LPS-stimulated elevation of pro-inflammatory mediators, such as inducible nitric oxide synthase iNOS, cyclooxygenase-2 COX-2, tumor necrosis factor TNF-alpha, interleukin IL-1beta and interleukin IL-6 in BV2 mouse brain microglia cells. Furthermore, licorice extract inhibited the expression levels of pro-inflammatory cytokines TNF-α, IL-1β and IL-6 in the livers of t-BHP-treated mice models. This result suggested that mechanistic-based evidence substantiating the traditional claims of licorice extract and its three bioactive components can be applied for the treatment of inflammation-related disorders, such as oxidative liver damage and inflammation diseases. View Full-Text

Keywords: licorice extract; oxidative liver damage; anti-inflammation; glycyrrhizic acid; liquiritin; hepatoprotective effect licorice extract; oxidative liver damage; anti-inflammation; glycyrrhizic acid; liquiritin; hepatoprotective effect





Author: Ji-Yeon Yu 1, Jae Yeo Ha 1, Kyung-Mi Kim 2, Young-Suk Jung 3, Jae-Chul Jung 2,* and Seikwan Oh 1,*

Source: http://mdpi.com/



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