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Institute of Electronics, Microelectronics and Nanotechnology IEMN, UMR 8520 CNRS, Lille1 University, Avenue Poincaré—BP 60069, 59652 Villeneuve d\Ascq, France


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Academic Editor: Derek J. McPhee

Abstract Multivalent interactions are omnipresent in biology and confer biological systems with dramatically enhanced affinities towards different receptors. Such multivalent binding interactions have lately been considered for the development of new therapeutic strategies against bacterial and viral infections. Multivalent polymers, dendrimers, and liposomes have successfully targeted pathogenic interactions. While a high synthetic effort was often needed for the development of such therapeutics, the integration of multiple ligands onto nanostructures turned to be a viable alternative. Particles modified with multiple ligands have the additional advantage of creating a high local concentration of binding molecules. This review article will summarize the different nanoparticle-based approaches currently available for the treatment of viral infections. View Full-Text

Keywords: viral infections; antiviral therapy; nanomaterials viral infections; antiviral therapy; nanomaterials

Author: Sabine Szunerits * , Alexandre Barras, Manakamana Khanal, Quentin Pagneux and Rabah Boukherroub



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