New Bergamotane Sesquiterpenoids from the Plant Endophytic Fungus Paraconiothyrium brasilienseReportar como inadecuado




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1

State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100190, China

2

State Key Laboratory of Toxicology & Medical Countermeasures, Beijing Institute of Pharmacology & Toxicology, Beijing 100850, China

3

University of Chinese Academy of Sciences, Beijing 100049, China





*

Authors to whom correspondence should be addressed.



Academic Editor: Derek J. McPhee

Abstract Brasilamides K-N 1–4, four new bergamotane sesquiterpenoids; with 4-oxatricyclo 3.3.1.0 2,7nonane 1and 9-oxatricyclo4.3.0.0 4,7nonane 2–4 skeletons; were isolated from the scale-up fermentation cultures of the plant endophytic fungus Paraconiothynium brasiliense Verkley. The previously identified sesquiterpenoids brasilamides A and C 5 and 6 were also reisolated in the current work. The structures of 1–4 were elucidated primarily by interpretation of NMR spectroscopic data. The absolute configurations of 1–3 were deduced by analogy to the co-isolated metabolites 5 and 6; whereas that of C-12 in 4 was assigned using the modified Mosher method. The cytotoxicity of all compounds against a panel of eight human tumor cell lines were assayed. View Full-Text

Keywords: Paraconiothynium brasiliense; endophytic fungus; sesquiterpenoid Paraconiothynium brasiliense; endophytic fungus; sesquiterpenoid





Autor: Zhe Guo 1,3, Fengxia Ren 2, Yongsheng Che 2, Gang Liu 1,* and Ling Liu 1,*

Fuente: http://mdpi.com/



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