Non-Covalent Derivatives: Cocrystals and EutecticsReport as inadecuate

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The Warner Babcock Institute for Green Chemistry, 100 Research Drive, Wilmington, MA 01887, USA

These authors contributed equally to this work.


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Academic Editor: Kei Saito

Abstract Non-covalent derivatives NCDs are formed by incorporating one or more coformer molecules into the matrix of a parent molecule via non-covalent forces. These forces can include ionic forces, Van der Waals forces, hydrogen bonding, lipophilic-lipophilic interactions and pi-pi interactions. NCDs, in both cocrystal and eutectic forms, possess properties that are unique to their supramolecular matrix. These properties include critical product performance factors such as solubility, stability and bioavailability. NCDs have been used to tailor materials for a variety of applications and have the potential to be used in an even broader range of materials and processes. NCDs can be prepared using little or no solvent and none of the reagents typical to synthetic modifications. Thus, NCDs represent a powerfully versatile, environmentally-friendly and cost-effective opportunity. View Full-Text

Keywords: non-covalent derivative; cocrystals; eutectics; green chemistry non-covalent derivative; cocrystals; eutectics; green chemistry

Author: Emily Stoler † and John C. Warner †,*



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