Characterization of the Sublimation and Vapor Pressure of 2-2-Nitrovinyl Furan G-0 Using Thermogravimetric Analysis: Effects of Complexation with CyclodextrinsReport as inadecuate




Characterization of the Sublimation and Vapor Pressure of 2-2-Nitrovinyl Furan G-0 Using Thermogravimetric Analysis: Effects of Complexation with Cyclodextrins - Download this document for free, or read online. Document in PDF available to download.

1

Departamento de Farmacia, Facultad de Química y Farmacia, Carretera a Camajuaní km 5½, Universidad Central de Las Villas, 54830 Villa Clara, Cuba

2

Department of Metallurgy and Material Engineering, Kasteelpark Arenberg 44, University of Leuven KU Leuven, BE-3001 Heverlee, Belgium

3

Centro de Bioactivos Químicos, Carretera a Camajuaní km 5½, Universidad Central de Las Villas, 54830 Villa Clara, Cuba

4

Drug Delivery and Disposition, Department of Pharmaceutical and Pharmacological Sciences, O & N2 Herestraat 49-Box 921, University of Leuven KU Leuven, BE-3000 Leuven, Belgium



These authors contributed equally to this work.





*

Author to whom correspondence should be addressed.



Academic Editors: Thomas Rades, Holger Grohganz and Korbinian Löbmann

Abstract In the present work, the sublimation of crystalline solid 2-2-nitrovinyl furan G-0 in the temperature range of 35 to 60 °C below the melting point of the drug was studied using thermogravimetric analysis TGA. The sublimated product was characterized using Fourier-transformed-infrared spectroscopy FT-IR and thin layer chromatography TLC. The sublimation rate at each temperature was obtained using the slope of the linear regression model and followed apparent zero-order kinetics. The sublimation enthalpy from 35 to 60 °C was obtained from the Eyring equation. The Gückel method was used to estimate the sublimation rate and vapor pressure at 25 °C. Physical mixtures, kneaded and freeze-dried complexes were prepared with 2-hydroxypropyl-β-cyclodextrin HP-β-CD and sulfobutyl ether-β-cyclodextrin SBE-β-CD and analyzed using isothermal TGA at 50 °C. The complexation contributed to reducing the sublimation process. The best results were achieved using freeze-dried complexes with both cyclodextrins. View Full-Text

Keywords: 2-2-nitrovinyl furan; cyclodextrins; thermogravimetry; sublimation enthalpy; vapor pressure 2-2-nitrovinyl furan; cyclodextrins; thermogravimetry; sublimation enthalpy; vapor pressure





Author: Vivian Ruz 1, Mirtha Mayra González 1,†, Danny Winant 2,†, Zenaida Rodríguez 3 and Guy Van den Mooter 4,*

Source: http://mdpi.com/



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