The Potential Use of Natural and Structural Analogues of Antimicrobial Peptides in the Fight against Neglected Tropical DiseasesReportar como inadecuado




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Centre of Excellence for Pharmaceutical Sciences PHARMACEN, North-West University, Potchefstroom 2520, South Africa





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Academic Editor: Thomas J. Schmidt

Abstract Recently, research into the development of new antimicrobial agents has been driven by the increase in resistance to traditional antibiotics and Emerging Infectious Diseases. Antimicrobial peptides AMPs are promising candidates as alternatives to current antibiotics in the treatment and prevention of microbial infections. AMPs are produced by all known living species, displaying direct antimicrobial killing activity and playing an important role in innate immunity. To date, more than 2000 AMPs have been discovered and many of these exhibit broad-spectrum antibacterial, antiviral and anti-parasitic activity. Neglected tropical diseases NTDs are caused by a variety of pathogens and are particularly wide-spread in low-income and developing regions of the world. Alternative, cost effective treatments are desperately needed to effectively battle these medically diverse diseases. AMPs have been shown to be effective against a variety of NTDs, including African trypanosomes, leishmaniosis and Chagas disease, trachoma and leprosy. In this review, the potential of selected AMPs to successfully treat a variety of NTD infections will be critically evaluated. View Full-Text

Keywords: antimicrobial peptides AMPs; neglected tropical diseases NTDs; malaria; parasites; antibacterial; antiviral; parasitic worms; innate immunity antimicrobial peptides AMPs; neglected tropical diseases NTDs; malaria; parasites; antibacterial; antiviral; parasitic worms; innate immunity





Autor: Angélique Lewies, Johannes Frederik Wentzel, Garmi Jacobs and Lissinda Hester Du Plessis *

Fuente: http://mdpi.com/



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