Ascorbic Acid-Initiated Tandem Radical Cyclization of N-Arylacrylamides to Give 3,3-Disubstituted OxindolesReportar como inadecuado




Ascorbic Acid-Initiated Tandem Radical Cyclization of N-Arylacrylamides to Give 3,3-Disubstituted Oxindoles - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

1

Hunan Co-Innovation Center for Utilization of Botanicals Functional Ingredients, Hunan Agricultural University, Changsha 410128, China

2

Pre-State Key Laboratory for Germplasm Innovation and Utilization of Crop, Hunan Agricultural University, Changsha 410128, China





*

Author to whom correspondence should be addressed.



Academic Editor: Derek J. McPhee

Abstract An ascorbic acid-promoted and metal-free tandem room temperature cyclization of N-arylacrylamides with 4-nitrobenzenediazonium generated in situ was developed. This reaction proceeds smoothly through a radical mechanism and provides an environmentally friendly alternative approach to biologically active 3-alkyl-3-benzyloxindoles, avoiding the use of excess oxidants and light irradiation. View Full-Text

Keywords: N-arylacrylamides; 3,3-disubstituted oxindoles; tandem cyclization; ascorbic acid; 4-nitroaniline N-arylacrylamides; 3,3-disubstituted oxindoles; tandem cyclization; ascorbic acid; 4-nitroaniline





Autor: Sheng Liu 1, Pi Cheng 1,2,* , Wei Liu 1 and Jian-Guo Zeng 1,2

Fuente: http://mdpi.com/



DESCARGAR PDF




Documentos relacionados