Review of Platensimycin and Platencin: Inhibitors of β-Ketoacyl-acyl Carrier Protein ACP Synthase III FabHReport as inadecuate




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1

Key Laboratory of New Animal Drug Project of Gansu Province, Key Laboratory of Veterinary Pharmaceutical Development, Ministry of Agriculture, Lanzhou Institute of Husbandry and Pharmaceutical Sciences of CAAS, Lanzhou 730050, China

2

Affiliated Hospital of Gansu University of Chinese Medicine, Lanzhou 730000, China





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Author to whom correspondence should be addressed.



Academic Editor: Peter J. Rutledge

Abstract Platensimycin and platencin were successively discovered from the strain Streptomyces platensis through systematic screening. These natural products have been defined as promising agents for fighting multidrug resistance in bacteria by targeting type II fatty acid synthesis with slightly different mechanisms. Bioactivity studies have shown that platensimycin and platencin offer great potential to inhibit many resistant bacteria with no cross-resistance or toxicity observed in vivo. This review summarizes the general information on platensimycin and platencin, including antibacterial and self-resistant mechanisms. Furthermore, the total synthesis pathways of platensimycin and platencin and their analogues from recent studies are presented. View Full-Text

Keywords: platensimycin; platencin; drug resistance; antibacterial activities; synthesis; analogues platensimycin; platencin; drug resistance; antibacterial activities; synthesis; analogues





Author: Ruofeng Shang 1, Jianping Liang 1, Yunpeng Yi 1, Yu Liu 1 and Jiatu Wang 2,*

Source: http://mdpi.com/



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