Structure and Antibacterial Activity of Ambobactin, a New Telomycin-Like Cyclic Depsipeptide Antibiotic Produced by Streptomyces ambofaciens F3Reportar como inadecuado




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College of Plant Protection, Northwest A & F University, Yangling 712100, Shanxi, China





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Academic Editor: Peter J. Rutledge

Abstract A new telomycin-like cyclic depsipeptide, ambobactin 1, was isolated from the metabolites of Streptomyces ambofaciens F3, an endophyte of Platycladus orientalis. Its structure was elucidated on the basis of extensive spectroscopic analysis and advanced Marfey’s method. Ambobactin is structurally related with telomycin, except that the configuration of the 3-methyltryptophanes in their structures is different. It exhibited strong antibacterial activity against both Gram-positive and Gram-negative bacteria. Furthermore, this investigation revealed that S. ambofaciens F3 is a new producer of telomycin-like antibiotics. View Full-Text

Keywords: cyclic depsipeptide; telomycin-like; Streptomyces ambofaciens F3; antibacterial activity cyclic depsipeptide; telomycin-like; Streptomyces ambofaciens F3; antibacterial activity





Autor: Shaopeng Wei, Wenhao Zhang and Zhiqin Ji *

Fuente: http://mdpi.com/



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