Synthesis and Evaluation of a Rationally Designed Click-Based Library for G-Quadruplex Selective DNA PhotocleavageReportar como inadecuado




Synthesis and Evaluation of a Rationally Designed Click-Based Library for G-Quadruplex Selective DNA Photocleavage - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

1

Department of Chemistry and Biochemistry, The University of Texas, Austin, TX 78712, USA

2

Division of Medicinal Chemistry, College of Pharmacy, The University of Texas, Austin, TX 78712, USA





*

Author to whom correspondence should be addressed.



Academic Editor: Ramon Eritja

Abstract DNA containing repeating G-rich sequences can adopt higher-order structures known as G-quadruplexes G4. These structures are believed to form within telomeres and the promoter regions of some genes, particularly in a number of proto-oncogenes, where they may play a role in regulating transcription. Alternatively, G4 DNA may act as a barrier to replication. To investigate these potential biological roles, probes that combine highly selective G4 DNA targeting with photocleavage activity can allow temporal detection of G4 DNA, providing opportunities to obtain novel insights about the biological roles of G4 DNA. We have designed, synthesized, and screened a small library of potential selective G-quadruplex DNA photocleavage agents incorporating the G-quadruplex targeting moiety of 360A with known photocleavage groups linked via -click- chemistry. View Full-Text

Keywords: DNA; photocleavage; alkyne-azide click reaction; PAGE DNA; photocleavage; alkyne-azide click reaction; PAGE





Autor: Dominic McBrayer 1 and Sean M. Kerwin 1,2,*

Fuente: http://mdpi.com/



DESCARGAR PDF




Documentos relacionados