Diterpenoids from the Endophytic Fungus Botryosphaeria sp. P483 of the Chinese Herbal Medicine Huperzia serrataReport as inadecuate




Diterpenoids from the Endophytic Fungus Botryosphaeria sp. P483 of the Chinese Herbal Medicine Huperzia serrata - Download this document for free, or read online. Document in PDF available to download.

1

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China

2

School of Pharmaceutical Sciences, Kunming Medical University, Kunming 650500, China





*

Author to whom correspondence should be addressed.



Academic Editor: Thomas J. Schmidt

Abstract Two new tetranorlabdane diterpenoids, named botryosphaerins G 1 and H 2, were isolated from the solid fermentation products of Botryosphaeria sp. P483 along with seven known tetranorlabdane diterpenes 3–9. Their structures were elucidated by extensive analysis, including 1D and 2D nuclear magnetic resonance NMR spectroscopy, and high-resolution electrospray ionization mass spectrometry HR-ESI-MS. Their absolute configuration was confirmed by single-crystal X-ray diffraction analyses using the anomalous scattering of Cu Kα radiation. All of the isolated compounds were tested for activity against phytopathogenic fungi and nematodes. Compounds 2 and 3 showed antifungal activity and compound 2 showed weak nematicidal activity. View Full-Text

Keywords: Botryosphaeria sp. P483; tetranorlabdane diterpenoid; X-ray crystallography; antifungal activity; nematicidal activity Botryosphaeria sp. P483; tetranorlabdane diterpenoid; X-ray crystallography; antifungal activity; nematicidal activity





Author: Yan-Mei Chen 1,2, Yin-He Yang 1, Xiao-Nian Li 1, Cheng Zou 2 and Pei-Ji Zhao 1,*

Source: http://mdpi.com/



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