Stereoselective Formation of Substituted 1,3-Dioxolanes through a Three-Component Assembly during the Oxidation of Alkenes with Hypervalent IodineIIIReport as inadecuate




Stereoselective Formation of Substituted 1,3-Dioxolanes through a Three-Component Assembly during the Oxidation of Alkenes with Hypervalent IodineIII - Download this document for free, or read online. Document in PDF available to download.

Graduate School of Material Science, University of Hyogo, Kohto, Kamigori, Hyogo 678-1297, Japan





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Academic Editors: Wesley Moran and Arantxa Rodríguez

Abstract Stereoselective formation of substituted 1,3-dioxolanes was achieved through an assembly of three components: alkene, carboxylic acid and silyl enol ether. The reaction proceeded via stereospecific generation of a 1,3-dioxolan-2-yl cation intermediate during oxidation of alkene substrates with hypervalent iodine. The stereoselective trapping of the cation intermediate with silyl enol ether completed the formation of the dioxolane product. View Full-Text

Keywords: hypervalent iodine; oxidation; dioxolane; dioxolanyl cation; stereoselective synthesis hypervalent iodine; oxidation; dioxolane; dioxolanyl cation; stereoselective synthesis





Author: Mio Shimogaki, Morifumi Fujita * and Takashi Sugimura

Source: http://mdpi.com/



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