New Hydrazones Bearing Thiazole Scaffold: Synthesis, Characterization, Antimicrobial, and Antioxidant InvestigationReport as inadecuate




New Hydrazones Bearing Thiazole Scaffold: Synthesis, Characterization, Antimicrobial, and Antioxidant Investigation - Download this document for free, or read online. Document in PDF available to download.

1

Department of Pharmaceutical Chemistry -Iuliu Hațieganu- University of Medicine and Pharmacy 41 Victor Babeș Street, RO-400012 Cluj-Napoca, Romania

2

State Veterinary Laboratory for Animal Health and Safety, 1 Piața Mărăști Street, 400609 Cluj-Napoca, Romania

3

Department of Pharmacognosy -Iuliu Hațieganu- University of Medicine and Pharmacy, 12 Ion Creangă Street, RO-400010 Cluj-Napoca, Romania





*

Author to whom correspondence should be addressed.



Academic Editor: Jean Jacques Vanden Eynde

Abstract New series of hydrazones 5–18 were synthesized, in good yields, by reacting 4-methyl-2-4-trifluoromethylphenylthiazole-5-carbohydrazide with differently substituted benzaldehyde. The resulting compounds were characterized via elemental analysis, physico-chemical and spectral data. An antimicrobial screening was done, using Gram +, Gram − bacteria and one fungal strain. Tested molecules displayed moderate-to-good growth inhibition activity. 2,2-Diphenyl-1-picrylhydrazide assay was used to test the antioxidant properties of the compounds. Monohydroxy 14–16, para-fluorine 13 and 2,4-dichlorine 17 derivatives exhibited better free-radical scavenging ability than the other investigated molecules. View Full-Text

Keywords: thiazole; hydrazide; acyl-hydrazone; antibacterial; antifungal; antioxidant thiazole; hydrazide; acyl-hydrazone; antibacterial; antifungal; antioxidant





Author: Cristina Nastasă 1,* , Brîndușa Tiperciuc 1, Mihaela Duma 2, Daniela Benedec 3 and Ovidiu Oniga 1

Source: http://mdpi.com/



DOWNLOAD PDF




Related documents