Synthesis of Biscoumarin and Dihydropyran Derivatives and Evaluation of Their Antibacterial ActivityReport as inadecuate




Synthesis of Biscoumarin and Dihydropyran Derivatives and Evaluation of Their Antibacterial Activity - Download this document for free, or read online. Document in PDF available to download.

1

School of Chemical Engineering, Xian University, Xian 710065, China

2

Department of Orthopaedics, Xijing Hospital, the Fourth Military Medical University, Xian 710032, China

3

Department of Pharmacology, School of Pharmacy, the Fourth Military Medical University, Xian 710032, China

4

Department of Neurosurgery, Xijing Hospital, the Fourth Military Medical University, Xian 710032, China



These authors contributed equally to this work.





*

Authors to whom correspondence should be addressed.



Academic Editor: Derek J. McPhee

Abstract In an attempt to find a new class antibacterial agents, a series of biscoumarins 1–4 and dihydropyrans 5–13 were successfully prepared. The molecular structures of four representative compounds, that is, 4, 5, 8 and 12 were confirmed by single crystal X-ray diffraction study. These synthesized compounds were screened for their antibacterial activity in vitro against Staphylococcus aureus S. aureus ATCC 29213, methicillin-resistant S. aureus MRSA XJ 75302, vancomycin-intermediate S. aureus Mu50 ATCC 700699, USA 300 Los Angeles County clone, LAC, Staphylococcus epidermidis S. epidermidis ATCC 14990, methicillin-resistant S. epidermidis MRSE XJ 75284 and Escherichia coli E. coli ATCC 25922. Additionally, there are two classical intramolecular O–H···O hydrogen bonds HBs in biscoumarins 1–4 and the corresponding HB energies were further performed with the density functional theory DFT B3LYP-6-31G* method. View Full-Text

Keywords: biscoumarins; dihydropyran; S. aureus; S. epidermidis biscoumarins; dihydropyran; S. aureus; S. epidermidis





Author: Jing Li 1,†, Chang-Wei Lv 2,†, Xiao-Jun Li 1, Di Qu 3, Zheng Hou 3, Min Jia 3, Xiao-Xing Luo 3, Xia Li 4,* and Ming-Kai Li 3,*

Source: http://mdpi.com/



DOWNLOAD PDF




Related documents