Identification of Minor Benzoylated 4-Phenylcoumarins from a Mammea neurophylla Bark ExtractReportar como inadecuado




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1

EA 921 SONAS, Université DAngers, SFR QUASAV 4207, Campus du Végétal, 42, rue Georges Morel, Beaucouzé 49070, France

2

Institut de Chimie des Substances Naturelles, CNRS UPR 2301, Université Paris-Saclay, 1, av. de la Terrasse, Gif-sur-Yvette 91198, France



These authors contributed equally to this work.





*

Author to whom correspondence should be addressed.



Academic Editor: Derek J. McPhee

Abstract Through dereplication analysis, seven known Mammea coumarins were identified in a fraction obtained from Mammea neurophylla dichloromethane bark extract selected for its ability to prevent advanced glycation end-product AGE formation. Among them, a careful examination of the NMR dataset of pedilanthocoumarin B led to a structural revision. Inspection of LC-DAD-MSn chromatograms allowed us to predict the presence of four new compounds, which were further isolated. Using spectroscopic methods 1H-, 13C- and 2D-NMR, HRMS, UV, these compounds were identified as new benzoyl substituted 4-phenylcoumarins iso-pedilanthocoumarin B and neurophyllol C and 4-1-acetoxypropylcoumarins cyclo F ochrocarpins H and I. View Full-Text

Keywords: 4-1-acetoxypropylcoumarins; benzoylcoumarins; Calophyllaceae; dereplication analysis; 4-phenylcoumarins 4-1-acetoxypropylcoumarins; benzoylcoumarins; Calophyllaceae; dereplication analysis; 4-phenylcoumarins





Autor: Bach Tai Dang 1,†, Caroline Rouger 1,†, Marc Litaudon 2, Pascal Richomme 1, Denis Séraphin 1 and Séverine Derbré 1,*

Fuente: http://mdpi.com/



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