Analysis of the Photophysical Behavior and Rotational-Relaxation Dynamics of Coumarin 6 in Nonionic Micellar Environments: The Effect of TemperatureReportar como inadecuado




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Department of Applied Physics II, Engineering School, University of Malaga, Malaga 29071, Spain



These authors contributed equally to this work.





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Academic Editor: Pascal Richomme

Abstract The photodynamics of Coumarin 6 have been investigated in three nonionic micellar assemblies, i.e., n-dodecyl-β-d-maltoside β-C12G2, p-tert-octyl-phenoxy polyethylene 9.5 ether Triton X-100 or TX100 and n-dodecyl-hexaethylene-glycol C12E6, to assess their potential use as encapsulation vehicles for hydrophobic drugs. To evaluate the effect of the micellar size and hydration, the study used a broad temperature range 293.15–323.15 K. The data presented here include steady-state absorption and emission spectra of the probe, dynamic light scattering, together with fluorescence lifetimes and both steady-state, as well as time-resolved fluorescence anisotropies. The time-resolved fluorescence anisotropy data were analyzed on the basis of the well-established two-step model. Our data reveal that the molecular probe in all of the cases is solubilized in the hydration layer of micelles, where it would sense a relatively polar environment. However, the probe was found to undergo a slower rotational reorientation when solubilized in the alkylpolyglycoside surfactant, as a result of a more compact microenvironment around the probe. The behavior of the parameters of the reorientation dynamics with temperature was analyzed on the basis of both micellar hydration and the head-group flexibility of the surfactants. View Full-Text

Keywords: Coumarin 6; n-dodecyl-β-d-maltoside; Triton X-100; n-dodecyl-hexaethylene-glycol; nonionic micellar assemblies; time-resolved fluorescence anisotropy Coumarin 6; n-dodecyl-β-d-maltoside; Triton X-100; n-dodecyl-hexaethylene-glycol; nonionic micellar assemblies; time-resolved fluorescence anisotropy





Autor: Cristóbal Carnero Ruiz †,* , José Manuel Hierrezuelo † and José Antonio Molina-Bolivar †

Fuente: http://mdpi.com/



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