A Practical Route for the Preparation of 1,4,7-Triazacyclononanyl Diacetates with a Hydroxypyridinonate Pendant ArmReport as inadecuate




A Practical Route for the Preparation of 1,4,7-Triazacyclononanyl Diacetates with a Hydroxypyridinonate Pendant Arm - Download this document for free, or read online. Document in PDF available to download.

School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China





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Academic Editor: Roman Dembinski

Abstract The preparation of triazamacrocyclic hydroxypyridinonate HOPO-TACN derivatives as potential chelators for metals in biomedical applications was reported. The synthesis is based on a convergent synthetic approach, in which the key intermediate di-tert-butyl-2,2′-1,4,7-triazonane-1,4-diyl diacetate was coupled with a hydroxypyridinonate pendant arm. The method is suitable for rapid syntheses of metal chelator HOPO-TACNs of biomedical interest. View Full-Text

Keywords: 1,4,7-triazonane; hydroxypyridinonate; metal chelator 1,4,7-triazonane; hydroxypyridinonate; metal chelator





Author: Yongkang Gai, Zhongping Hu, Zhao Rong, Xiang Ma * and Guangya Xiang *

Source: http://mdpi.com/



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