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1

Center for Biotechnology Research in UBITA CBRU, Institute for Ubiquitous Information Technology and Applications UBITA, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Korea

2

Microbial Carbohydrate Resource Bank MBRC, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Korea

3

Department of Bioscience and Biotechnology, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Korea





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Academic Editor: Holger Grohganz

Abstract In this review, a comprehensive overview of advances in the supramolecular complexes of carbohydrates and poorly soluble drugs is presented. Through the complexation process, poorly soluble drugs could be efficiently delivered to their desired destinations. Carbohydrates, the most abundant biomolecules, have diverse physicochemical properties owing to their inherent three-dimensional structures, hydrogen bonding, and molecular recognition abilities. In this regard, oligosaccharides and their derivatives have been utilized for the bioavailability enhancement of hydrophobic drugs via increasing the solubility or stability. By extension, polysaccharides and their derivatives can form self-assembled architectures with poorly soluble drugs and have shown increased bioavailability in terms of the sustained or controlled drug release. These supramolecular systems using carbohydrate will be developed consistently in the field of pharmaceutical and medical application. View Full-Text

Keywords: poorly soluble drugs; carbohydrates; supramolecular complexation; bioavailability enhancement poorly soluble drugs; carbohydrates; supramolecular complexation; bioavailability enhancement





Autor: Eunae Cho 1 and Seunho Jung 1,2,3,*

Fuente: http://mdpi.com/



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