Anti-Inflammatory Activity Comparison among Scropoliosides—Catalpol Derivatives with 6-O-Substituted Cinnamyl MoietiesReport as inadecuate




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1

Murad Research Institute for Modernized Chinese Medicine, Shanghai University of Traditional Chinese Medicine

2

School of Pharmacy, Shanghai University of Traditional Chinese Medicine



These authors contributed equally to this work.





*

Authors to whom correspondence should be addressed.



Academic Editor: Derek J. McPhee

Abstract We have previously shown that scropolioside B has higher anti-inflammatory activity than catalpol does after the inhibition of nuclear factor NF-κB activity and IL-1β expression, maturation, and secretion. Various scropoliosides were extracted, isolated, and purified from Scrophularia dentata Royle ex Benth. We then compared their anti-inflammatory activities against LPS-induced NF-κB activity, cytokines mRNA expression, IL-1β secretion, and cyclooxygenase-2 activity. The inhibitory effects of the scropoliosides varied depending on whether the 6-O-substituted cinnamyl moiety was linked to C′′ 2-OH, C′′3-OH, or C′′4-OH, and on the number of moieties linked, which is closely related to the enhancement of antiinflammatory activity. Among these compounds, scropolioside B had the strongest antiinflammatory effects. View Full-Text

Keywords: scropoliosides; 6-O-substituted cinnamyl moiety; antiinflammatory effect; NF-κB; cytokines scropoliosides; 6-O-substituted cinnamyl moiety; antiinflammatory effect; NF-κB; cytokines





Author: Tiantian Zhu 1,2,†, Liuqiang Zhang 2,†, Shuang Ling 1, Fei Qian 1,2, Yiming Li 2,* and Jin-Wen Xu 1,*

Source: http://mdpi.com/



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