Role of the Red Ginseng in Defense against the Environmental Heat Stress in Sprague Dawley RatsReportar como inadecuado




Role of the Red Ginseng in Defense against the Environmental Heat Stress in Sprague Dawley Rats - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

1

Department of Food Science and Biotechnology, College of Life Science, CHA University, Kyonggi 463-400, Korea

2

Korea Food Research Institute, Kyonggi, Seongnam 463-746, Korea



These authors contributed equally to this work.





*

Author to whom correspondence should be addressed.



Academic Editor: Christopher W. K. Lam

Abstract Global temperature change causes heat stress related disorders in humans. A constituent of red ginseng has been known the beneficial effect on the resistance to many diseases. However, the mechanism of red ginseng RG against heat stress still remains unclear. To determine the effect of RG on heat stress, we examined the effect of the RG on the gene expression profiles in rats subjected to environmental heat stress. We evaluated the transcripts associated with hepatic lipid accumulation and oxidative stress in rats subjected to heat stress. We also analyzed the reactive oxygen species ROS contents. Our results suggested RG inhibited heat stress mediated altering mRNA expressions include HSPA1, DEAF1, HMGCR, and FMO1. We also determined RG attenuated fat accumulation in the liver by altering C-EBPβ expression. RG promoted to repress the heat stress mediated hepatic cell death by inhibiting of Bcl-2 expression in rats subjected to heat stress. Moreover, RG administered group during heat stress dramatically decreased the malondialdehyde MDA contents and ROS associated genes compared with the control group. Thus, we suggest that RG might influence inhibitory effect on environmental heat stress induced abnormal conditions in humans. View Full-Text

Keywords: red ginseng; herbal medicine; heat environmental stress; lipid peroxidation; lipid accumulation; ginsenoside red ginseng; herbal medicine; heat environmental stress; lipid peroxidation; lipid accumulation; ginsenoside





Autor: Kui-Jin Kim 1,†, Kye-Yoon Yoon 1,†, Hee-Do Hong 2 and Boo-Yong Lee 1,*

Fuente: http://mdpi.com/



DESCARGAR PDF




Documentos relacionados