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Medicinal Chemistry and Pharmacology Institute, Inner Mongolia University for the Nationalities, Tongliao 028000, China


Affiliated Hospital of Inner Mongolia University for Nationalities, Tongliao 028000, Inner Mongolia, China

These authors contributed equally to this work.


Author to whom correspondence should be addressed.

Academic Editor: Derek J. McPhee

Abstract Epilepsy affects about 1% of the world’s population. Due to the fact all antiepileptic drugs AEDs have some undesirable side effects and about 30% of epileptic patients are not seizure-free with the existing AEDs, there is still an urgent need for the development of more effective and safer AEDs. Based on our research work on antiepileptic compounds and other references in recent years, this review covers the reported work on antiepileptic compounds which are classified according to their structures. This review summarized 244 significant anticonvulsant compounds which are classified by functional groups according to the animal model data, although there are some limitations in the data. This review highlights the properties of new compounds endowed with promising antiepileptic properties, which may be proven to be more effective and selective, and possibly free of unwanted side effects. The reviewed compounds represent an interesting possibility to overcome refractory seizures and to reduce the percentage of patients with a poor response to drug therapy. View Full-Text

Keywords: epilepsy; antiepileptic compounds; structure activity relationship epilepsy; antiepileptic compounds; structure activity relationship

Author: Cheng-Xi Wei 1,†, Ming Bian 1,† and Guo-Hua Gong 1,2,*



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