Quaternary Alkylammonium Conjugates of Steroids: Synthesis, Molecular Structure, and Biological StudiesReport as inadecuate




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Laboratory of Microbiocides Chemistry, Faculty of Chemistry, Adam Mickiewicz University, Umultowska 89b, 61-614 Poznań, Poland





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Academic Editor: Roman Dembinski

Abstract The methods of synthesis as well as physical, spectroscopic 1H-NMR, 13C-NMR, and FT-IR, ESI-MS, and biological properties of quaternary and dimeric quaternary alkylammonium conjugates of steroids are presented. The results were contrasted with theoretical calculations PM5 methods and potential pharmacological properties PASS. Alkylammonium sterols exhibit a broad spectrum of antimicrobial activity comparable to squalamine. View Full-Text

Keywords: squalamine; bile acids; sterols; quaternary alkylammonium salt; conjugates; prediction of activity spectra for substances PASS; PM5 calculations squalamine; bile acids; sterols; quaternary alkylammonium salt; conjugates; prediction of activity spectra for substances PASS; PM5 calculations





Author: Bogumił Brycki * , Hanna Koenig and Tomasz Pospieszny

Source: http://mdpi.com/



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