Ultrasound-Assisted Extraction, Antioxidant and Anticancer Activities of the Polysaccharides from Rhynchosia minima RootReport as inadecuate




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State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau 999078, China





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Academic Editor: Jianbo Xiao

Abstract Box-Behnken design BBD, one of the most common response surface methodology RSM methods, was used to optimize the experimental conditions for ultrasound-assisted extraction of polysaccharides from Rhynchosia minima root PRM. The antioxidant abilities and anticancer activity of purified polysaccharide fractions were also measured. The results showed that optimal extraction parameters were as follows: ultrasound exposure time, 21 min; ratio of water to material, 46 mL-g; ultrasound extraction temperature, 63 °C. Under these conditions, the maximum yield of PRM was 16.95% ± 0.07%. Furthermore, the main monosaccharides of purified fractions were Ara and Gal. PRM3 and PRM5 exhibited remarkable DPPH radical scavenging activities and reducing power in vitro. PRM3 showed strong inhibitory activities on the growth of MCF-7 cells in vitro. The above results indicate that polysaccharides from R. minima root have the potential to be developed as natural antioxidants and anticancer ingredients for the food and pharmaceutical industries. View Full-Text

Keywords: Rhynchosia minima root; polysaccharide; ultrasound-assisted extraction; antioxidant activity; anticancer activity Rhynchosia minima root; polysaccharide; ultrasound-assisted extraction; antioxidant activity; anticancer activity





Author: Xuejing Jia, Chao Zhang, Jie Hu, Muxue He, Jiaolin Bao, Kai Wang, Peng Li, Meiwan Chen, Jianbo Wan, Huanxing Su, Qingwen Zhang and Chengwei He *

Source: http://mdpi.com/



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