New Flavones, a 2-2-Phenylethyl-4H-chromen-4-one Derivative, and Anti-Inflammatory Constituents from the Stem Barks of Aquilaria sinensisReportar como inadecuado




New Flavones, a 2-2-Phenylethyl-4H-chromen-4-one Derivative, and Anti-Inflammatory Constituents from the Stem Barks of Aquilaria sinensis - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

1

School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, Taiwan

2

Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan

3

Research Center for Industry of Human Ecology and Graduate Institute of Health Industry Technology, Chang Gung University of Science and Technology, Taoyuan 33302, Taiwan

4

Immunology Consortium, Chang Gung Memorial Hospital, Taoyuan 33302, Taiwan

5

National Museum of Marine Biology and Aquarium, Pingtung 94450, Taiwan

6

Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung 81362, Taiwan

7

Bioresource Collection and Research Center BCRC, Food Industry Research and Development Institute FIRDI, Hsinchu 30062, Taiwan

8

Department of Pharmacy, Tajen University, Pingtung 90741, Taiwan



These authors contributed equally to this work.





*

Author to whom correspondence should be addressed.



Academic Editors: Nancy D. Turner and Isabel C. F. R. Ferreira

Abstract In the current study, two new flavones, 4′-O-geranyltricin 1 and 3′-O-geranylpolloin 2, and a new 2-2-phenylethyl-4H-chromen-4-one derivative, 7-hydroxyl-6-methoxy-2-2-phenylethylchromone 3, have been isolated from the stem barks of A. sinensis, together with 21 known compounds 4–24. The structures of new compounds 1–3 were determined through spectroscopic and MS analyses. Compounds 2, 3, 5, 6, and 8–10 exhibited inhibition IC50 ≤ 12.51 μM of superoxide anion generation by human neutrophils in response to formyl-l-methionyl-l-leucyl-l-phenylalanine-cytochalasin B fMLP-CB. Compounds 3, 6, 8, 10, and 19 inhibited fMLP-CB-induced elastase release with IC50 values ≤ 15.25 μM. This investigation reveals bioactive isolates especially 2, 3, 5, 6, 8, 9, 10, and 19 could be further developed as potential candidates for the treatment or prevention of various inflammatory diseases. View Full-Text

Keywords: Aquilaria sinensis; Thymelaeaceae; structure elucidation; flavone; 2-2-phenylethyl-4H-chromen-4-one; anti-inflammatory activity Aquilaria sinensis; Thymelaeaceae; structure elucidation; flavone; 2-2-phenylethyl-4H-chromen-4-one; anti-inflammatory activity





Autor: Sin-Ling Wang 1,†, Tsong-Long Hwang 2,3,4, Mei-Ing Chung 1,†, Ping-Jyun Sung 5, Chih-Wen Shu 6, Ming-Jen Cheng 7 and Jih-Jung Chen 8,*

Fuente: http://mdpi.com/



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