Algae Undaria pinnatifida Protects Hypothalamic Neurons against Endoplasmic Reticulum Stress through Akt-mTOR SignalingReportar como inadecuado




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1

Institute of Medical Research, Dongguk University College of Medicine, Gyeongju 38066, Korea

2

Department of Anatomy, Dongguk University College of Medicine, Gyeongju 38066, Korea

3

Department of Biochemistry, Dongguk University College of Medicine, Gyeongju 38066, Korea

4

Department of Internal Medicine, Dongguk University College of Medicine, Gyeongju 38066, Korea





*

Authors to whom correspondence should be addressed.



Academic Editor: Derek J. McPhee

Abstract Increased endoplasmic reticulum ER stress is known to be one of the causes of hypothalamic neuronal damage, as well as a cause of metabolic disorders such as obesity and diabetes. Recent evidence has suggested that Undaria pinnatifida UP, an edible brown algae, has antioxidant activity. However, the neuroprotective effect of UP has yet to be examined. In this study, to investigate the neuroprotective effect of UP on ER stress-induced neuronal damage in mouse hypothalamic neurons, mice immortal hypothalamic neurons GT1-7 were incubated with extract of UP. ER stress was induced by treating with tunicamycin. Tunicamycin induced apoptotic cell death was compared with the vehicle treatment through excessive ER stress. However UP protected GT1-7 cells from cell death, occurring after treatment with tunicamycin by reducing ER stress. Treatment with UP resulted in reduced increment of ATF6 and CHOP, and recovered the decrease of phosphorylation of Akt-mTOR by tunicamycin and the increment of autophagy. These results show that UP protects GT1-7 cells from ER stress induced cell death through the Akt-mTOR pathway. The current study suggests that UP may have a beneficial effect on cerebral neuronal degeneration in metabolic diseases with elevated ER stress. View Full-Text

Keywords: Undaria pinnatifida; ER stress; apoptosis; autophagy; hypothalamus Undaria pinnatifida; ER stress; apoptosis; autophagy; hypothalamus





Autor: Jongwan Kim 1,2, Il Soo Moon 2, Tae-Won Goo 3, Seong-Su Moon 1,4,* and Minchul Seo 1,*

Fuente: http://mdpi.com/



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