A GC-MS Based Metabonomics Study of Rheumatoid Arthritis and the Interventional Effects of the Simiaowan in RatsReportar como inadecuado




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1

School of Traditional Chinese Materia Medica, Tianjin University of TCM, 312 Anshan West Road, Nankai District, Tianjin 300193, China

2

Tianjin State Key Laboratory of Modern Chinese Medicine, No. 88, Yuquan Road, Nankai District, Tianjin 300193, China





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Author to whom correspondence should be addressed.



Academic Editor: Derek J. McPhee

Abstract Simiaowan SMW is a famous Chinese prescription widely used in clinical treatment of rheumatoid arthritis RA. The aim of the present study is to determine novel biomarkers to increase the current understanding of RA mechanisms, as well as the underlying therapeutic mechanism of SMW, in RA-model rats. Plasma extracts from control, RA model, and SMW-treated rats were analyzed by gas chromatography coupled with mass spectrometry GC-MS. An orthogonal partial least-square discriminant analysis OPLS-DA model was created to detect metabolites that were expressed in significantly different amounts between the RA model and the control rats and investigate the therapeutic effect of SMW. Metabonomics may prove to be a valuable tool for determining the efficacy of complex traditional prescriptions. View Full-Text

Keywords: GC-MS; metabonomics; rheumatoid arthritis; Simiaowan GC-MS; metabonomics; rheumatoid arthritis; Simiaowan





Autor: Yuming Wang 1,2, Xuejun Guo 1,2, Jiabin Xie 1,2, Zhiguo Hou 1,2 and Yubo Li 1,2,*

Fuente: http://mdpi.com/



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