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1

Department of Chemistry, College of Science, Engineering and Technology, University of South Africa, P. O. Box 392, Pretoria 0003, South Africa

2

Department of Life and Consumer Sciences, College of Agriculture and Environmental Sciences, University of South Africa, Private Bag X06, FL 1710, South Africa





*

Author to whom correspondence should be addressed.



Academic Editor: Derek J. McPhee

Abstract Amination of the 2-aryl-6-bromo-4-chloro-8-iodoquinazolines with 2-aminoethanol followed by acid-promoted cyclodehydration of the incipient 2-6,8-dihalo-2-phenylquinazolin-4-ylaminoethanols afforded the corresponding novel 5-aryl-9-bromo-7-iodo-2,3-dihydro-2H-imidazo1,2-cquinazolines. The latter were, in turn, subjected to sequential Sonogashira and Suzuki-Miyaura and one-pot two-step Sonogashira-Stille cross-coupling reactions to afford diversely functionalized polycarbo-substituted 2H-imidazo1,2-cquinazolines. The imidazoquinazolines were screened for in vitro cytotoxicity against human breast adenocarcinoma MCF-7 cells and human cervical cancer HeLa cells. View Full-Text

Keywords: dihalogenated 2H-imidazo1,2-cquinazolines; cross-coupling; imidazo1,2-cquinazolines; cytotoxicity dihalogenated 2H-imidazo1,2-cquinazolines; cross-coupling; imidazo1,2-cquinazolines; cytotoxicity





Autor: Tebogo Ankie Khoza 1, Tshepiso Jan Makhafola 2 and Malose Jack Mphahlele 1,*

Fuente: http://mdpi.com/



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