Heterocycles 36. Single-Walled Carbon Nanotubes-Bound N,N-Diethyl Ethanolamine as Mild and Efficient Racemisation Agent in the Enzymatic DKR of 2-Arylthiazol-4-yl-alaninesReport as inadecuate




Heterocycles 36. Single-Walled Carbon Nanotubes-Bound N,N-Diethyl Ethanolamine as Mild and Efficient Racemisation Agent in the Enzymatic DKR of 2-Arylthiazol-4-yl-alanines - Download this document for free, or read online. Document in PDF available to download.

1

Department of Organic Chemistry -Iuliu Haţieganu- University of Medicine and Pharmacy, RO-400012 Cluj-Napoca, Victor Babeş 41, Romania

2

Biocatalysis and Biotransformation Research Group, Babeş-Bolyai University, RO-400028 Cluj-Napoca, Arany János 11, Romania





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Academic Editor: Derek J. McPhee

Abstract In this paper we describe the chemoenzymatic synthesis of enantiopure l-2-arylthiazol-4-yl alanines starting from their racemic N-acetyl derivatives; by combining the lipase-catalysed dynamic kinetic resolution of oxazol-54H-ones with a chemical and an enzymatic enantioselective hydrolytic step affording the desired products in good yields 74%–78% and high enantiopurities ee > 99%. The developed procedure exploits the utility of the single-walled carbon nanotubes-bound diethylaminoethanol as mild and efficient racemisation agent for the dynamic kinetic resolution of the corresponding oxazolones. View Full-Text

Keywords: hydrolases; dynamic kinetic resolution; racemisation agent; l-α-amino acids; thiazole hydrolases; dynamic kinetic resolution; racemisation agent; l-α-amino acids; thiazole





Author: Denisa Leonte 1, László Csaba Bencze 2, Csaba Paizs 2, Monica Ioana Toşa 2, Valentin Zaharia 1,* and Florin Dan Irimie 2,*

Source: http://mdpi.com/



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