Synthesis, Biological Evaluation and Molecular Docking Studies of 6-Aryl-2-Styrylquinazolin-43H-OnesReport as inadecuate




Synthesis, Biological Evaluation and Molecular Docking Studies of 6-Aryl-2-Styrylquinazolin-43H-Ones - Download this document for free, or read online. Document in PDF available to download.

1

Department of Chemistry, College of Science, Engineering and Technology, University of South Africa, P. O. Box 392, Pretoria 0003, South Africa

2

Department of Life and Consumer Sciences, College of Agriculture and Environmental Sciences, University of South Africa, Private Bag X06, Florida 1710, South Africa

3

Institute for Research in Molecular Medicine INFORMM, Universiti Sains Malaysia, 11800 Minden, Penang, Malaysia

4

Computational Chemistry Group, Department of Chemistry, Faculty of Science, University of Mauritius, Réduit 80837, Mauritius





*

Author to whom correspondence should be addressed.



Academic Editor: Derek J. McPhee

Abstract Suzuki-Miyaura cross-coupling of 6-bromo-2-styrylquinazolin-43H-ones with arylboronic acids afforded a series of novel 6-aryl-2-styrylquinazolin-43H-ones. These compounds were evaluated for potential anticancer properties against the human renal TK-10, melanoma UACC-62 and breast cancer MCF-7 cell lines. Their antimicrobial properties were also evaluated against six Gram-positive and four Gram-negative bacteria, as well as two strains of fungi. Molecular docking studies in silico were conducted on compounds 5a, b, d and 6a, b, d–f to recognize the hypothetical binding motif of the title compounds within the active site of the dihydrofolate reductase and thymidylate synthase enzymes. View Full-Text

Keywords: 6-bromo-2-styrylquinazolin-43H-ones; Suzuki-Miyaura cross-coupling; 6-aryl-2-styrylquinazolin-43H-ones; in vitro cytotoxicity; antimicrobial activity; docking studies 6-bromo-2-styrylquinazolin-43H-ones; Suzuki-Miyaura cross-coupling; 6-aryl-2-styrylquinazolin-43H-ones; in vitro cytotoxicity; antimicrobial activity; docking studies





Author: Emmanuel Ndubuisi Agbo 1, Tshepiso Jan Makhafola 2, Yee Siew Choong 3, Malose Jack Mphahlele 1,* and Ponnadurai Ramasami 4

Source: http://mdpi.com/



DOWNLOAD PDF




Related documents