New Phragmalin-Type Limonoids from Chukrasia tabularis and Their α-Glucosidase Inhibitory ActivityReportar como inadecuado




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1

Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China

2

College of Pharmacy and Chemistry, Dali University, Dali 671000, China



These authors contributed equally to this work.





*

Authors to whom correspondence should be addressed.



Academic Editors: John Beutler and Fernando Albericio

Abstract Phytochemical investigation on the stems of C. tabularis led to the isolation of five new phragmalin-type limonoids and six known ones. The structures of the new compounds 1–5, named chukbularisins A–E, were elucidated by spectroscopic techniques IR, HRESIMS, 1D and 2D NMR and comparisons with published data. All the compounds were evaluated for in vitro α-glucosidase inhibitory activity. Compounds 2, 3, 4, 5, and 8 exhibited inhibitory activity against α-glucosidase with IC50 values of 0.06 ± 0.008, 0.04 ± 0.002, 0.52 ± 0.039, 1.09 ± 0.040, and 0.20 ± 0.057 mM, respectively using acarbose as positive control, IC50 0.95 ± 0.092 mM. View Full-Text

Keywords: Chukrasia tabularis; Meliaceae; limonoid; α-Glucosidase inhibition activity Chukrasia tabularis; Meliaceae; limonoid; α-Glucosidase inhibition activity





Autor: Jun-Lin Peng 1,2,†, Jun Wang 1,†, Fan-Dong Kong 1, Zi-Qi Liu 2, Pei Wang 1, Cui-Juan Gai 1, Bei Jiang 2, Wen-Li Mei 1,* and Hao-Fu Dai 1,*

Fuente: http://mdpi.com/



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