Nutrition Composition and Single, 14-Day and 13-Week Repeated Oral Dose Toxicity Studies of the Leaves and Stems of Rubus coreanus MiquelReportar como inadecuado




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1

Laboratory of Food Safety and Toxicology, Department of Food Science and Nutrition, Hanyang University, Seoul 133-791, Korea

2

Functional Food and Nutrition Division, Department of Agrofood Resources, National Academy of Agricultural Science, Jeonbuk 565-851, Korea





*

Author to whom correspondence should be addressed.



Academic Editor: Derek J. McPhee

Abstract The leaves and stems of the plant Rubus coreanus Miquel RCMLS are rich in vitamins, minerals and phytochemicals which have antioxidant, anti-hemolytic, anti-inflammatory, anti-fatigue and anti-cancer effects. However, RCMLS is not included in the Korean Food Standards Codex due to the lack of safety assurance concerning RCMLS. We evaluated single and repeated oral dose toxicity of RCMLS in Sprague-Dawley rats. RCMLS did not induce any significant toxicological changes in both male and female rats at a single doses of 2500 mg-kg-day. Repeated oral dose toxicity studies showed no adverse effects in clinical signs, body weight, food consumption, ophthalmic examination, urinalysis, hematology, serum biochemistry, necropsy findings, organ weight, and histopathology at doses of 625, 1250, and 2500 mg-kg-day. The LD50 and LOAEL of RCMLS might be over 2500 mg-kg body weight-day and no target organs were identified. Therefore, this study revealed that single and repeated oral doses of RCMLS are safe. View Full-Text

Keywords: Rubus coreanus Miquel leaves and stems; single dose toxicity; repeated dose toxicity; nutrition composition Rubus coreanus Miquel leaves and stems; single dose toxicity; repeated dose toxicity; nutrition composition





Autor: Ae-Son Om 1,* , Yu-Na Song 1, GeonMin Noh 2, HaengRan Kim 2 and JeongSook Choe 2

Fuente: http://mdpi.com/



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