The Protective Effects of HJB-1, a Derivative of 17-Hydroxy-Jolkinolide B, on LPS-Induced Acute Distress Respiratory Syndrome MiceReportar como inadecuado




The Protective Effects of HJB-1, a Derivative of 17-Hydroxy-Jolkinolide B, on LPS-Induced Acute Distress Respiratory Syndrome Mice - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

1

Central Laboratory, The Second Clinical Hospital, Jilin University, Changchun 130041, China

2

Key Laboratory of Zoonosis, Ministry of Education, Institute of Zoonosis, Jilin University, Changchun 130062, China

3

School of Life Sciences and Technology, Tongji University, Shanghai 200092, China

4

Key Laboratory of Molecular Enzymology and Engineering, Ministry of Education, College of Life Science, Jilin University, Changchun 130012, China

5

Jilin Provincial Center for Disease Control and Prevention, Changchun 130062, China



These authors contributed equally to this work.





*

Authors to whom correspondence should be addressed.



Academic Editor: Norbert Latruffe

Abstract Acute respiratory distress syndrome ARDS,which is inflammatory disorder of the lung, which is caused by pneumonia, aspiration of gastric contents, trauma and sepsis, results in widespread lung inflammation and increased pulmonary vascular permeability. Its pathogenesis is complicated and the mortality is high. Thus, there is a tremendous need for new therapies. We have reported that HJB-1, a 17-hydroxy-jolkinolide B derivative, exhibited strong anti-inflammatory effects in vitro. In this study, we investigated its impacts on LPS-induced ARDS mice. We found that HJB-1 significantly alleviated LPS-induced pulmonary histological alterations, inflammatory cells infiltration, lung edema, as well as the generation of inflammatory cytokines TNF-α, IL-1β and IL-6 in BALF. In addition, HJB-1 markedly suppressed LPS-induced IκB-α degradation, nuclear accumulation of NF-κB p65 subunit and MAPK phosphorylation. These results suggested that HJB-1 improved LPS-induced ARDS by suppressing LPS-induced NF-κB and MAPK activation. View Full-Text

Keywords: Acute respiratory distress syndrome ARDS; NF-κB; MAPK; 17-hydroxy-jolkinolide B; edema Acute respiratory distress syndrome ARDS; NF-κB; MAPK; 17-hydroxy-jolkinolide B; edema





Autor: Xiaohan Xu 1,2,3,†, Ning Liu 1,†, Yu-Xin Zhang 4, Jinjin Cao 1, Donglin Wu 5, Qisheng Peng 2, Hong-Bing Wang 3,* and Wan-Chun Sun 1,2,*

Fuente: http://mdpi.com/



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