An Unusual Stress Metabolite from a Hydrothermal Vent Fungus Aspergillus sp. WU 243 Induced by CobaltReportar como inadecuado




An Unusual Stress Metabolite from a Hydrothermal Vent Fungus Aspergillus sp. WU 243 Induced by Cobalt - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

1

Ocean College, Zhejiang University, Hangzhou 310058, China

2

Institute of Marine Geology and Chemistry, National Sun Yat-sen University, Kaohsiung 80424, Taiwan

3

Department of Applied Chemistry, Zhejiang Gongshang University, Hangzhou 310058, China





*

Author to whom correspondence should be addressed.



Academic Editor: Maxim L. Kuznetsov

Abstract A novel hybrid polyketide-terpenoid, aspergstressin 1, possessing a unique fused polycyclic structure, was induced from culture broth of strain Aspergillus sp. WU 243 by cobalt ion stimulation. The strain was isolated from the digestive gland of Xenograpsus testudinatus, a unique type of crab which dwells in the Kueishantao hydrothermal vents off Taiwan. The chemical structure and relative configuration of the stress metabolite were established by spectroscopic means. Aspergillus sp. WU 243 produced aspergstressin 1 only under cobalt stressed culture conditions. The results show that stress-driven discovery of new natural products from hydrothermal vent fungi is an effective strategy to unveil the untapped reservoir of small molecules from species found in the hydrothermal vent environment. View Full-Text

Keywords: marine fungi; metal-stress; hydrothermal vent; marine natural products marine fungi; metal-stress; hydrothermal vent; marine natural products





Autor: Chihong Ding 1, Xiaodan Wu 1, Bibi Nazia Auckloo 1, Chen-Tung Arthur Chen 1,2, Ying Ye 1, Kuiwu Wang 3 and Bin Wu 1,*

Fuente: http://mdpi.com/



DESCARGAR PDF




Documentos relacionados