The Suppressive Effects of Cinnamomi Cortex and Its Phytocompound Coumarin on Oxaliplatin-Induced Neuropathic Cold Allodynia in RatsReportar como inadecuado


The Suppressive Effects of Cinnamomi Cortex and Its Phytocompound Coumarin on Oxaliplatin-Induced Neuropathic Cold Allodynia in Rats


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1

Department of Physiology, College of Korean Medicine, Kyung Hee University, 26 Kyunghee-daero, Dongdamoon-gu, Seoul 02447, Korea

2

Department of Science in Korean Medicine, Graduate School, Kyung Hee University, 26 Kyunghee-daero, Dongdamoon-gu, Seoul 02447, Korea

3

Department of Anesthesiology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, 573 Xujiahui Rd., Dapiqiao, Huangpu Qu, Shanghai 200025, China

4

Department of Herbology, College of Korean Medicine, Kyung Hee University, 26 Kyunghee-daero, Dongdamoon-gu, Seoul 02447, Korea





*

Authors to whom correspondence should be addressed.



Academic Editor: Luigia Trabace

Abstract Oxaliplatin, a chemotherapy drug, induces acute peripheral neuropathy characterized by cold allodynia, spinal glial activation and increased levels of pro-inflammatory cytokines. Herein, we determined whether Cinnamomi Cortex C. Cortex, a widely used medicinal herb in East Asia for cold-related diseases, could attenuate oxaliplatin-induced cold allodynia in rats and the mechanisms involved. A single oxaliplatin injection 6 mg-kg, i.p. induced significant cold allodynia signs based on tail immersion tests using cold water 4 °C. Daily oral administration of water extract of C. Cortex WECC 100, 200, and 400 mg-kg for five consecutive days following an oxaliplatin injection dose-dependently alleviated cold allodynia with only a slight difference in efficacies between the middle dose at 200 mg-kg and the highest dose at 400 mg-kg. WECC at 200 mg-kg significantly suppressed the activation of astrocytes and microglia and decreased the expression levels of IL-1β and TNF in the spinal cord after injection with oxaliplatin. Furthermore, oral administration of coumarin 10 mg-kg, a major phytocompound of C. Cortex, markedly reduced cold allodynia. These results indicate that C. Cortex has a potent anti-allodynic effect in oxaliplatin-injected rats through inhibiting spinal glial cells and pro-inflammatory cytokines. We also suggest that coumarin might play a role in the anti-allodynic effect of C. Cortex. View Full-Text

Keywords: Cinnamomi Cortex; cold allodynia; coumarin; glia; spinal cord; pro-inflammatory cytokines Cinnamomi Cortex; cold allodynia; coumarin; glia; spinal cord; pro-inflammatory cytokines





Autor: Changmin Kim 1,†, Ji Hwan Lee 2,†, Woojin Kim 1, Dongxing Li 3, Yangseok Kim 1, Kyungjin Lee 4,* and Sun Kwang Kim 1,2,*

Fuente: http://mdpi.com/



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