Antiprotozoal and Antiglycation Activities of Sesquiterpene Coumarins from Ferula narthex ExudateReportar como inadecuado


Antiprotozoal and Antiglycation Activities of Sesquiterpene Coumarins from Ferula narthex Exudate


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1

Natural Products & Food Research and Analysis NatuRA, Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium

2

Laboratory of Parasitology, Microbiology and Hygiene LMPH, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium





*

Author to whom correspondence should be addressed.



Academic Editor: Thomas J. Schmidt

Abstract The exudate of Ferula narthex Boiss. Apiaceae is widely used in the Indian subcontinent as a spice and because of its health effects. Six sesquiterpene coumarins have been isolated from this exudate: feselol, ligupersin A, asacoumarin A, 8′-O-acetyl-asacoumarin A, 10′R-karatavacinol and 10′R-acetyl-karatavacinol. Based on its use in infectious and diabetic conditions, the isolated constituents were evaluated for antimicrobial and antiglycation activities. Some compounds showed activity against protozoal parasites, asacoumarin A being the most active one against Plasmodium falciparum K1 IC50 1.3 μM. With regard to antiglycation activity, in the BSA-glucose test, ligupersin A displayed the highest activity IC50 0.41 mM, being more active than the positive control aminiguanidine IC50 1.75 mM. In the BSA-MGO assay, the highest activity was shown by 8′-O-acetyl-asacoumarin A IC50 1.03 mM, being less active than aminoguanidine IC50 0.15 mM. Hence, the antiglycation activity of the isolated constituents was due to both oxidative and non-oxidative modes of inhibition. View Full-Text

Keywords: Ferula narthex; exudate; Apiaceae; sesquiterpene coumarins; antiprotozoal activity; antiglycation activity Ferula narthex; exudate; Apiaceae; sesquiterpene coumarins; antiprotozoal activity; antiglycation activity





Autor: Adnan Amin 1, Emmy Tuenter 1, Paul Cos 2, Louis Maes 2, Vassiliki Exarchou 1, Sandra Apers 1 and Luc Pieters 1,*

Fuente: http://mdpi.com/



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