Terminamines K–S, Antimetastatic Pregnane Alkaloids from the Whole Herb of Pachysandra terminalisReportar como inadecuado


Terminamines K–S, Antimetastatic Pregnane Alkaloids from the Whole Herb of Pachysandra terminalis


Terminamines K–S, Antimetastatic Pregnane Alkaloids from the Whole Herb of Pachysandra terminalis - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Tianjin Key Laboratory on Technologies Enabling Development Clinical Therapeutics and Diagnostics Theranostics, School of Pharmacy, Research Center of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China





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Academic Editor: Derek J. McPhee

Abstract Nine new pregnane alkaloids 1–9, together with eight known alkaloids 10–17, were isolated from the whole herb of Pachysandra terminalis. Their structures were elucidated on the basis of spectroscopic analyses. In addition, the isolates were examined for their ability to inhibit the migration of MDA-MB-231 cells induced by the chemokine epidermal growth factor EGF. Alkaloids 1, 5, 7, 9, 12, and 17 presented significant anti-metastasis activities compared with the positive reagent, LY294002. View Full-Text

Keywords: Pachysandra terminalis; Buxaceae; pregnane alkaloids; anti-metastatic activity; structure-activity relationships Pachysandra terminalis; Buxaceae; pregnane alkaloids; anti-metastatic activity; structure-activity relationships





Autor: Xiang-Yu Li, Yang Yu, Miao Jia, Mei-Na Jin, Nan Qin, Chuan Zhao * and Hong-Quan Duan *

Fuente: http://mdpi.com/



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