Ellagitannins of Davidia involucrata. I. Structure of Davicratinic Acid A and Effects of Davidia Tannins on Drug-Resistant Bacteria and Human Oral Squamous Cell CarcinomasReportar como inadecuado


Ellagitannins of Davidia involucrata. I. Structure of Davicratinic Acid A and Effects of Davidia Tannins on Drug-Resistant Bacteria and Human Oral Squamous Cell Carcinomas


Ellagitannins of Davidia involucrata. I. Structure of Davicratinic Acid A and Effects of Davidia Tannins on Drug-Resistant Bacteria and Human Oral Squamous Cell Carcinomas - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

1

Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8530, Japan

2

Department of Molecular Microbiology and Biotechnology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan

3

Division of Pharmacology, Department of Diagnostic and Therapeutic Sciences, School of Dentistry, Meikai University, Saitama 350-0283, Japan





*

Author to whom correspondence should be addressed.



Academic Editor: Derek J. McPhee

Abstract We isolated a new ellagitannin, davicratinic acid A 5, together with four known ellagitannins, davidiin 1, granatin A 2, pedunculagin 3, and 3-O-galloylgranatin A 4, from an aqueous acetone extract of dried Davidia involucrata leaves. The known ellagitannins were identified based on spectroscopic data. The structure of davicratinic acid A 5, a monomeric ellagitannin possessing a unique, skew-boat glucopyranose core, was established based on spectroscopic data. Additionally, we examined the effects of several tannins with good yields from this plant on drug-resistant bacteria and human oral squamous cell carcinomas, and found that davidiin 1 exhibited the most potent antibacterial and antitumor properties among the tannins examined. View Full-Text

Keywords: Davidia involucrata; ellagitannin; anti-bacterial effect; antitumor effect; davicratinic acid A Davidia involucrata; ellagitannin; anti-bacterial effect; antitumor effect; davicratinic acid A





Autor: Yuuki Shimozu 1, Yuriko Kimura 1, Akari Esumi 1, Hiroe Aoyama 1, Teruo Kuroda 2, Hiroshi Sakagami 3 and Tsutomu Hatano 1,*

Fuente: http://mdpi.com/



DESCARGAR PDF




Documentos relacionados